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Post-surgical recovery affecting multiple tissue types, chronic widespread inflammation, and patients whose primary complaint is global stiffness and reduced range of motion that has not improved with localized treatment all fit the TB-500 indication
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Severe AWS involves changes in electrolytes, especially potassium that is due to increased catecholamine activity with activation of the sodium–potassium ATPase pump and elevated vasopressin.25 Hypokalemia is not specific for alcohol consumption but is frequently reported to be associated with DT or seizures.10, 25, 28, 29 The same applies to thrombocytopenia (with high negative predictive value)10, 24, 25, 29, 30 that additionally is predictive of an incident occurrence of DT and seizures.25 More indirect markers, such as AST, ALT, γGT, and MCV, are widely available and relatively inexpensive, but their predictive value is restricted because of low specificity
